Polyphenol-assisted assembly of Au-deposited polylactic acid microneedles for SERS sensing and antibacterial photodynamic therapy

3D SERS microneedles with self-assembled AuNPs were fabricated with tannic acid (chemical glue and reductant) on polylactic acid microneedles for in-depth chemical and biomolecular analysis, with LOD values below 200 ppb for small molecules and 10 2 CFU cm −2 for bacteria. The MB/Au-microneedles wer...

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Published inChemical communications (Cambridge, England) Vol. 59; no. 42; pp. 6339 - 6342
Main Authors Chia, Zi-Chun, Chen, Yi-Lun, Chuang, Cheng-Hsun, Hsieh, Chou-Hsun, Chen, Ya-Jyun, Chen, Kuan-Hsu, Huang, Tzu-Chi, Chen, Mei-Chin, Huang, Chih-Chia
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 23.05.2023
Subjects
Gold - chemistry
Metal Nanoparticles - chemistry
Needles
Photochemotherapy
Photodynamic therapy
Polylactic acid
Polyphenols
Reducing agents
Self-assembly
Spectrum Analysis, Raman
Tannic acid
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Summary:3D SERS microneedles with self-assembled AuNPs were fabricated with tannic acid (chemical glue and reductant) on polylactic acid microneedles for in-depth chemical and biomolecular analysis, with LOD values below 200 ppb for small molecules and 10 2 CFU cm −2 for bacteria. The MB/Au-microneedles were used for photodynamic therapy with SERS-monitored photosensitizer degradation. The polyphenol-assisted assembly of an Au-deposited microneedle array and the methylene blue-immobilized microneedle array were designed for in situ SERS-based bacteria sensing and antibacterial photodynamic therapy, respectively.
Bibliography:Electronic supplementary information (ESI) available. See DOI
https://doi.org/10.1039/d3cc00733b
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1359-7345
1364-548X
DOI:10.1039/d3cc00733b