Serum non-high-density lipoprotein cholesterol levels and the incidence of ischemic stroke in a Japanese population: the Jichi Medical School cohort study

The predictive value of serum non-high-density lipoprotein cholesterol (non-HDL-C) levels for the incidence of ischemic stroke and its subtypes has not yet been established. The present cohort study investigated their relationships in a Japanese population. The first incidence of ischemic stroke and...

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Published inAsia-Pacific journal of public health Vol. 27; no. 2; p. NP535
Main Authors Kakehi, Eiichi, Kotani, Kazuhiko, Ishikawa, Shizukiyo, Gotoh, Tadao, Kayaba, Kazunori, Nakamura, Yosikazu, Kajii, Eiji
Format Journal Article
LanguageEnglish
Published China 01.03.2015
Subjects
Adult
Aged
Aged, 80 and over
Biomarkers
Brain Ischemia - epidemiology
Cholesterol - blood
Cholesterol - classification
Cholesterol, HDL - blood
Cohort Studies
Female
Humans
Incidence
Japan - epidemiology
Male
Middle Aged
Proportional Hazards Models
Prospective Studies
Risk Factors
Schools, Medical
Sex Factors
Stroke - epidemiology
Young Adult
Japan
ischemic stroke subtypes
population-based survey
ischemic stroke
non-high-density lipoprotein cholesterol
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ISSN1941-2479
DOI10.1177/1010539513475649

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Summary:The predictive value of serum non-high-density lipoprotein cholesterol (non-HDL-C) levels for the incidence of ischemic stroke and its subtypes has not yet been established. The present cohort study investigated their relationships in a Japanese population. The first incidence of ischemic stroke and its subtypes was documented as the primary outcome. A total of 249 ischemic stroke patients (men/women = 145/104) were identified during a follow-up period of 10.7 years among 10 760 community-dwelling subjects (men/women = 4212/6548). Cox proportional hazard model analyses revealed that when compared with the lowest tertile of non-HDL-C, multivariate-adjusted hazard ratios for the highest tertile were 0.55 (95% confidence interval = 0.32-0.95, P = .03) on ischemic stroke and 0.29 (95% confidence interval = 0.08-1.05, P = .06) on cardioembolic infarction in women. Men did not show such significant relationships. Low serum non-HDL-C levels may be a predictive marker associated with an increase in the incidence of ischemic stroke and possibly of cardioembolic infarction in Japanese women.
ISSN:1941-2479
DOI:10.1177/1010539513475649