Lewis acid mediated cyclization: synthesis of 2 spirocyclohexylindolines

Herein, we report the synthesis of 2-spirocyclohexylindolines based on a Lewis acid mediated cyclization. This diastereoselective procedure provides the target structures in a straightforward way via dual activation. Herein, we report the synthesis of 2-spirocyclohexylindolines based on a Lewis acid...

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Bibliographic Details
Published inOrganic & biomolecular chemistry Vol. 19; no. 18; pp. 443 - 447
Main Authors Kong, Xiang-Kai, Xiong, Zhi-Min, Zhi, Xiang, Meng, Xue-Ling, Zhao, Jing-Feng, Chen, Wen, Zhang, Hongbin
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 12.05.2021
Royal Society of Chemistry
Subjects
Chemistry
Chemistry, Organic
Crystallography
Lewis acid
Physical Sciences
Science & Technology
Stereoselectivity
Synthesis
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Summary:Herein, we report the synthesis of 2-spirocyclohexylindolines based on a Lewis acid mediated cyclization. This diastereoselective procedure provides the target structures in a straightforward way via dual activation. Herein, we report the synthesis of 2-spirocyclohexylindolines based on a Lewis acid mediated cyclization.
Bibliography:Electronic supplementary information (ESI) available. CCDC
2048988-2048993
For ESI and crystallographic data in CIF or other electronic formats see DOI
2071825
and
10.1039/d1ob00293g
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1477-0520
1477-0539
DOI:10.1039/d1ob00293g