Synthesis of deuterium-labeled DL-threo-thiamphenicol

A convenient and inexpensive approach for the synthesis of deuterium-labeled thiamphenicol was described. DL - threo -Thiamphenicol-methyl- d 3 was prepared with high chemical purity and isotopic enrichment via a six-step process starting from 4-bromobenzaldehyde and DMSO- d 6 by employing microwave...

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Bibliographic Details
Published inJournal of radioanalytical and nuclear chemistry Vol. 324; no. 3; pp. 1463 - 1467
Main Authors Zhang, Meihui, Zhang, Lizhi, Wang, Wei, Yan, Tingchang, Xu, Liying, Dong, Jinhua
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 01.06.2020
Springer
Springer Nature B.V
Subjects
Chemistry
Chemistry and Materials Science
Deuterium
Diagnostic Radiology
Diastereomers
Hadrons
Heavy Ions
Inorganic Chemistry
Isotopes
Isotopic enrichment
Nuclear Chemistry
Nuclear Physics
Pharmaceutical biotechnology
Physical Chemistry
Asymmetric aziridination
Deuterium-labeled thiamphenicol
Synthesis
Methylthiolation
Microwave reaction
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Summary:A convenient and inexpensive approach for the synthesis of deuterium-labeled thiamphenicol was described. DL - threo -Thiamphenicol-methyl- d 3 was prepared with high chemical purity and isotopic enrichment via a six-step process starting from 4-bromobenzaldehyde and DMSO- d 6 by employing microwave-assisted copper-mediated methylthiolation and modified Wulff’s asymmetric aziridination.
ISSN:0236-5731
1588-2780
DOI:10.1007/s10967-020-07155-z