Simultaneous determination of codeine, caffeine, butalbital, and aspirin by free solution capillary electrophoresis

• Published in: Journal of liquid chromatography & related technologies Vol. 22; no. 8; pp. 1193 - 1204
• Main Authors: Haque, A, Stewart, J.T
• Format: Journal Article
• Language: English
• Published: Colchester Taylor & Francis Group 1999; Taylor & Francis
• Subjects: Analysis; Biological and medical sciences; General pharmacology; Medical sciences; Pharmacology. Drug treatments; quantitative analysis; separation; Chemical analysis; Zone electrophoresis; Morphine derivatives; Capillary electrophoresis; Opiates; Acetylsalicylic acid; Mobile phase; Butalbital; Analgesic; Multicomponent analysis; Ultraviolet detector; Simultaneous measurement; Antipyretic; Dosage form; pH; Tablet; Xanthine derivatives; Salicylates; Barbiturates; Quantitative analysis; Caffeine

A free solution capillary electrophoresis method was developed to separate and quantitate codeine (CD), caffeine (CF), butalbital (BB), and aspirin (AP) in a mixture. The mixture was injected hydrodynamically for 5s at the anodic end and separation was performed on a fused silica capillary (72 cm ×...