Antimosquito and Antimicrobial Clerodanoids and a Chlorobenzenoid from Tessmannia species

• Published in: Natural product communications Vol. 5; no. 2; pp. 175 - 178
• Main Authors: Kihampa, Charles, Nkunya, Mayunga H.H., Joseph, Cosam C., Magesa, Stephen M., Hassanali, Ahmed, Heydenreich, Matthias, Kleinpeter, Erich
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.02.2010
• Subjects: Animals; Anopheles - drug effects; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antifungal Agents - chemistry; Antifungal Agents - pharmacology; Chlorobenzenes - chemistry; Chlorobenzenes - pharmacology; Diterpenes, Clerodane - chemistry; Diterpenes, Clerodane - pharmacology; Fabaceae - chemistry; Insecticides - chemistry; Insecticides - pharmacology; Larva - drug effects; Molecular Structure; T. martiniana var martiniana; chlorobenzenoid; anti-mosquitoes; ent-clerodanoids; Tessmannia martiniana var pauloi; Caesalpiniaceae; antimicrobials
• ISSN: 1934-578X; 1555-9475
• DOI: 10.1177/1934578X1000500201

The clerodane diterpenoids trans-kolavenolic acid, 18-oxocleroda-3,13(E)-dien-15-oic acid, ent-(18-hydroxycarbonyl)-cleroda-3,13(E)-dien-15-oate, 2-oxo-ent-cleroda-3,13(Z)-dien-15-oic acid and trans-2-oxo-ent-cleroda-13(Z)-en-15-oic acid, and the chlorobenzenoid O-(3-hydroxy-4-hydroxycarbonyl-5-pentylphenyl)-3-chloro-4-methoxy-6-pentyl-2-oxybenzoic acid were isolated from Tessmannia martiniana var pauloi and T. martiniana var matiniana. Structures were established based on interpretation of spectroscopic data. Some of the compounds exhibited significant antimosquito, antifungal and antibacterial activities.