The protective effects of beta-mangostin against sodium iodate-induced retinal ROS-mediated apoptosis through MEK/ERK and p53 signaling pathways

• Published in: Food & function Vol. 14; no. 24; pp. 1896 - 199
• Main Authors: Chang, Yuan-Yen, Wang, Meilin, Yeh, Jui-Hsuan, Tsou, Shang-Chun, Chen, Tzu-Chun, Hsu, Min-Yen, Lee, Yi-Ju, Wang, Inga, Lin, Hui-Wen
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 11.12.2023
• Subjects: Age; Age related diseases; Animals; Apoptosis; Caspase 3 - genetics; Caspase 3 - metabolism; Caspase-3; Catalase; Cell viability; Cellular manufacture; Damage; Down-regulation; Epithelium; Eye diseases; Glutathione; Hydrogen peroxide; Hydrogen Peroxide - metabolism; Intracellular signalling; Macular degeneration; MEK inhibitors; Mitochondrial Diseases; Mitogen-Activated Protein Kinase Kinases - metabolism; Oxidative Stress; p53 Protein; Phosphorylation; Reactive oxygen species; Reactive Oxygen Species - metabolism; Retina; Retinal Pigment Epithelium; Signal Transduction; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism

Previous studies have indicated that NaIO 3 induces intracellular reactive oxygen species (ROS) production and has been used as a model for age-related macular degeneration (AMD) due to the selective retinal pigment epithelium (RPE) cell damage it induces. Beta-mangostin (BM) is a xanthone-type natu...