Contrast-induced nephropathy in patients with ST elevation myocardial infarction treated with primary percutaneous coronary intervention

• Published in: Angiology Vol. 65; no. 1; p. 37
• Main Authors: Elbasan, Zafer, Şahin, Durmuş Yildiray, Gür, Mustafa, Kuloğlu, Osman, Kivrak, Ali, Içen, Yahya Kemal, Türkoglu, Caner, Yildirim, Arafat, Özdogru, Ibrahim, Çayli, Murat
• Format: Journal Article
• Language: English
• Published: United States 01.01.2014
• Subjects: Adult; Aged; Contrast Media - adverse effects; Coronary Angiography - adverse effects; Female; Humans; Kidney Diseases - blood; Kidney Diseases - chemically induced; Kidney Diseases - diagnostic imaging; Male; Middle Aged; Myocardial Infarction - blood; Myocardial Infarction - diagnostic imaging; Myocardial Infarction - therapy; Percutaneous Coronary Intervention - adverse effects; Prevalence; Uric Acid - blood; nephropathy; SYNTAX score; uric acid; contrast media; myocardial infarction
• ISSN: 1940-1574
• DOI: 10.1177/0003319712463816

We assessed the relationship between contrast-induced nephropathy (CIN) and SYNTAX score (SS) and serum uric acid (SUA) levels in patients with ST elevation myocardial infarction (STEMI). A total of 835 STEMI patients in whom primary percutaneous coronary intervention was performed in our cardiology clinic were included in this study (615 male, 220 female; mean age 58.1 ± 12.2 years). The patients were divided into 2 groups (CIN and non-CIN). Contrast-induced nephropathy was observed in 9.6% (80) of patients; SS (13.9 ± 6.2/22.1 ± 5.8) and SUA (5.1 ± 0.9/6.2 ± 0.9) values in the CIN group were higher compared with the non-CIN group (P < .001, for all). All SS (95% confidence interval [CI] = 1.136-1.250, P = .001), SUA (95% CI = 1.877-3.236, P = .002), and diabetes (95% CI = 0.998-1.039, P = .026) were independent predictors of CIN in logistic regression analysis. Procedures that can prevent CIN may be beneficial in patients at high risk as identified by the SS and SUA levels.