Semiconductor nanocrystal-polymer hybrid nanomaterials and their application in molecular imprinting
Quantum dots (QDs) are attractive semiconductor fluorescent nanomaterials with remarkable optical and electrical properties. The broad absorption spectra and high stability of QD transducers are advantageous for sensing and bioimaging. Molecular imprinting is a technique for manufacturing synthetic...
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| Published in | Nanoscale Vol. 11; no. 25; pp. 123 - 1274 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Royal Society of Chemistry
07.07.2019
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Quantum dots (QDs) are attractive semiconductor fluorescent nanomaterials with remarkable optical and electrical properties. The broad absorption spectra and high stability of QD transducers are advantageous for sensing and bioimaging. Molecular imprinting is a technique for manufacturing synthetic polymeric materials with a high recognition ability towards a target analyte. The high selectivity of the molecularly imprinted polymers (MIPs) is a result of the fabrication process based on the template-tailored polymerization of functional monomers. The three-dimensional cavities formed in the polymer network can serve as the recognition elements of sensors because of their specificity and stability. Appending specific molecularly imprinted layers to QDs is a promising strategy to enhance the stability, sensitivity, and selective fluorescence response of the resulting sensors. By merging the benefits of MIPs and QDs, inventive optical sensors are constructed. In this review, the recent synthetic strategies used for the fabrication of QD nanocrystals emphasizing various approaches to effective functionalization in aqueous environments are discussed followed by a detailed presentation of current advances in QD conjugated MIPs (MIP-QDs). Frontiers in manufacturing of specific imprinted layers of these nanomaterials are presented and factors affecting the specific behaviour of an MIP shell are identified. Finally, current limitations of MIP-QDs are defined and prospects are outlined to amplify the capability of MIP-QDs in future sensing.
An essential survey of semiconductor nanocrystal-polymer hybrid nanomaterials and their application in molecular imprinting is presented. |
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| Bibliography: | Piotr Bujak received his MSc in chemistry from Silesian University of Technology 2004. In 2008, at the University of Silesia he defended his Ph.D thesis devoted to the NMR investigations of copolymers. Then he started working at the Department of Inorganic and Coordination Chemistry (University of Silesia), where he developed an effective method for the synthesis of new isoxazolines. In 2012 he accepted the position of a research associate at the Warsaw University of Technology, joining the group of Professor Adam Pron, where he presently works at an associate professor position, focusing on the preparation of electroactive hybrids consisting of inorganic semiconductor nanocrystals functionalized with low and high molecular mass organic semiconductors. Monika Sobiech received her PhD in Pharmacy from the Medical University of Warsaw in 2016. She is presently an assistant professor at the Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Warsaw. Her current research interests focus on the computational modelling, preparation, and characterization of molecularly imprinted polymers and their applications in different areas such as separation, sensing and drug delivery. Adam Pron was born (1951) and educated in Poland. After obtaining his MSc in chemistry he moved to the USA where in 1980 he completed his PhD at the University of Pennsylvania (under the supervision of Alan G. MacDiarmid). Then he joined the Warsaw University of Technology where he became full professor in 1993. In 1998 he moved to the Atomic Energy Commission (CEA) in Grenoble (France). In 2012 he retired from the CEA and accepted full-time professorship at the Warsaw University of Technology. His research interests include preparation and characterization of organic electroactive materials and hybrid organic-inorganic nanomaterials. Piotr Lulinski completed his PhD in 2002. He is an associate professor at the Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Poland. Molecularly imprinted polymers (MIPs) are the main topic of his scientific interest. His studies are focused on the synthesis, characterization and application of MIPs for biomedical and pharmaceutical purposes. In his papers the fundamental investigations and the practical aspects of MIP applications are emphasized. He is also involved in the examination of potential drug delivery vehicles based on MIPs. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 2040-3364 2040-3372 |
| DOI: | 10.1039/c9nr02585e |