Correlation between Argus II array-retina distance and electrical thresholds of stimulation is improved by measuring the entire array

• Published in: European journal of ophthalmology Vol. 31; no. 1; p. 194
• Main Authors: Xu, Lucy T, Rachitskaya, Aleksandra V, DeBenedictis, Meghan J, Bena, James, Morrison, Shannon, Yuan, Alex
• Format: Journal Article
• Language: English
• Published: United States 01.01.2021
• Subjects: Aged; Electric Stimulation; Female; Humans; Male; Microelectrodes; Middle Aged; Prosthesis Implantation; Retina - physiology; Retinitis Pigmentosa - diagnostic imaging; Retinitis Pigmentosa - physiopathology; Retinitis Pigmentosa - surgery; Sensory Thresholds - physiology; Tomography, Optical Coherence; Visual Perception - physiology; Visual Prosthesis; retinitis pigmentosa; optical coherence tomography; Argus; array–retina distance
• ISSN: 1724-6016
• DOI: 10.1177/1120672119885799

To describe two methods of measuring Argus II array-retina distance and to correlate array-retina distance to electrode stimulation thresholds. This was a case series of eight patients implanted with the Argus II. Spectral domain-optical coherence tomography array-retina distance was measured by two methods and correlated to corresponding electrode thresholds: (1) array-retina distance at each array corner and the largest array-retina distance and (2) using manual optical coherence tomography segmentation, the average array-retina distance was determined for each group of four electrodes. Patients 1-5 and 6-8 were analyzed separately due to a different threshold programming software. The Spearman's rank coefficient between array-retina distance and thresholds was -0.006 (  = 0.98) for patients 1-5, and 0.16 (  = 0.59) for patients 6-8 with the first method. The Spearman's rank coefficient was 0.25 (  < 0.001) for patients 1-5 and 0.36 (  < 0.001) for patients 6-8 with the second method. There is a positive correlation between array-retina distance and threshold measurements when measuring the entire array but not when using a faster measurement method of four corners and largest array-retina distance.