Detection of antibodies to leptospiral genus-specific antigen in human and animal sera by indirect hemagglutination test with a partially purified genus-specific protein antigen

Antibodies against leptospiral genus-specific antigen were detected in the sera from clinically diagnosed human leptospirosis and suspected animal leptospirosis by indirect hemagglutination (IHA) test with a partially purified genus-specific protein antigen (GP-Ag). The reaction was positive in the...

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Published inZentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology Vol. 259; no. 4; p. 548
Main Authors Sakamoto, N, Yanagawa, R, Ono, E, Kida, H, Mori, M, Arimitsu, Y, Akama, K, Yasuda, J, Too, K
Format Journal Article
LanguageEnglish
Published Germany 01.07.1985
Subjects
Animals
Antibodies, Bacterial - analysis
Antibody Specificity
Antigens, Bacterial - immunology
Bacterial Proteins - immunology
Cattle
Cattle Diseases - immunology
Dog Diseases - immunology
Dogs
Hemagglutination Tests - veterinary
Humans
Leptospira - immunology
Leptospirosis - immunology
Leptospirosis - veterinary
Swine
Swine Diseases - immunology
Weil Disease - immunology
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Summary:Antibodies against leptospiral genus-specific antigen were detected in the sera from clinically diagnosed human leptospirosis and suspected animal leptospirosis by indirect hemagglutination (IHA) test with a partially purified genus-specific protein antigen (GP-Ag). The reaction was positive in the infected humans and animals irrespective of the leptospiral serovars. No significant correlation was found between IHA titer against GP-Ag and microscopic agglutination (MA) titer. IHA titer did not always develop in parallel with MA titers. Sera obtained from healthy individuals were negative in both IHA and MA tests.
ISSN:0176-6724
DOI:10.1016/S0176-6724(85)80087-0