Modulating confinement space in metal-organic frameworks enables highly selective indole C3-formylation

Here, Selective C3-formylation of indole was achieved under mild conditions using a metal-organic framework (MOF) catalyst. The confined reaction space within the MOF pores effectively suppressed undesired side reactions and promoted the formation of the targeted product by controlling the reaction...

Full description

Saved in:
Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 6; no. 44; pp. 5715 - 5718
Main Authors Zheng, Deng-Yue, Zhang, Tianjian, Bai, Rongxian, Li, Minghao, Gu, Yanlong
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 28.05.2024
Subjects
Density functional theory
Metal-organic frameworks
Online AccessGet full text

Cover

More Information
Summary:Here, Selective C3-formylation of indole was achieved under mild conditions using a metal-organic framework (MOF) catalyst. The confined reaction space within the MOF pores effectively suppressed undesired side reactions and promoted the formation of the targeted product by controlling the reaction pathway. Density functional theory (DFT) calculations corroborated the experimental observations. MOF confinement catalysis can hinder the reaction of orthoformate and indole to form the trimethoxymethane compounds, thereby creating indole C3 formaldehyde compounds.
Bibliography:https://doi.org/10.1039/d4cc01629g
Electronic supplementary information (ESI) available. See DOI
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/d4cc01629g