Pathology and Genetics of Syndromic Gastric Polyps

• Published in: International journal of surgical pathology Vol. 24; no. 3; p. 185
• Main Authors: Brosens, Lodewijk A A, Wood, Laura D, Offerhaus, G Johan, Arnold, Christina A, Lam-Himlin, Dora, Giardiello, Francis M, Montgomery, Elizabeth A
• Format: Journal Article
• Language: English
• Published: United States 01.05.2016
• Subjects: Adenomatous Polyps - genetics; Adenomatous Polyps - pathology; Humans; Stomach Neoplasms - genetics; Stomach Neoplasms - pathology; McCune-Albright syndrome; gastric cancer; gastric polyp; hamartomatous polyp; juvenile polyposis; neurofibromatosis type 1; Cronkhite-Canada syndrome; Peutz-Jeghers; familial adenomatous polyposis; polyposis; Lynch syndrome
• ISSN: 1940-2465
• DOI: 10.1177/1066896915620013

Gastric polyps are found in 1% to 4% of patients undergoing gastroscopy. The vast majority are sporadic, but some gastric polyps indicate an underlying syndrome. Gastric polyps can manifest in each of the gastrointestinal polyposis syndromes, including the recently described gastric adenocarcinoma and proximal polyposis of the stomach syndrome. In addition, gastric polyps occur in Lynch syndrome and in a few rare conditions that are not primarily gastrointestinal. While some of these syndromes are clearly associated with an increased risk of gastric cancer, others are not. Interestingly, even in disorders with a well-established risk of gastric cancer, the neoplastic potential and the precursor status of these gastric polyps are not always clear. Although rare, recognition of syndromic gastric polyps is important for individual patient management. These conditions also serve as important models to study gastric homeostasis and gastric tumorigenesis.