Tetrazine bioorthogonal chemistry makes nanotechnology a powerful toolbox for biological applications

Bioorthogonal chemistry enables researchers to manipulate bioactive molecules in living systems. These highly selective and biocompatible reactions can be carried out in various complex environments. Over the past two decades, a considerable number of strides have been made to expand the capacities...

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Bibliographic Details
Published inNanoscale Vol. 15; no. 2; pp. 461 - 469
Main Authors Zhang, Renshuai, Gao, Jiake, Zhao, Gaoxiang, Zhou, Liman, Kong, Fandong, Jiang, Tao, Jiang, Hongfei
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 05.01.2023
Subjects
Biocompatibility
Biomolecules
Chemistry
Chemists
Click Chemistry
Medical imaging
Nanomaterials
Nanotechnology
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Summary:Bioorthogonal chemistry enables researchers to manipulate bioactive molecules in living systems. These highly selective and biocompatible reactions can be carried out in various complex environments. Over the past two decades, a considerable number of strides have been made to expand the capacities of bioorthogonal chemistry coupled with the aim to fine-tune present reactions for specific applications. The good points of bioorthogonal chemistry have pushed material chemists to integrate bioorthogonal chemistry with nanotechnologies to broaden the biological applications of nanomaterials. Notably, bioorthogonal nanotechnologies fundamentally rely on, more than half, according to our investigation, tetrazine bioorthogonal chemistry (TBC) to function as bioorthogonal handles to react with target agents owing to the extremely rapid kinetics and high selectivities of TBC. Its utilization in combination with nanotechnologies has led to developments in various areas of biomedicine, such as in situ drug activation and targeted delivery, bioimaging and biosensing, and the understanding of cell-biomolecule interactions. Given the fantastic past achievements and the rapid developments in tetrazine bioorthogonal technologies, the future is certainly very bright. The incorporation of tetrazine bioorthogonal chemistry with nanoparticles has greatly expanded the biological applications of nanotechnologies.
Bibliography:Dr Jiang revived her PhD in Changchun Institute of applied Chemistry, Chinese Academic of Sciences. After that she studied in Hong Kong Baptist University for her post-doctoral training. She joined the Marine Drug and Food Institute of Ocean University of China in 1997. During 2004-2005, she worked in Lady Davis Institute, Jewis General Hospital in Canada for cooperative research. Dr Jiang's research focus on developing novel sensors for biomolecule imaging and modulation. She has lead and took 23 research projects and published over 100 peer-reviewed papers
Renshuai Zhang is an assistant professor in the Affiliated Hospital of Qingdao University. He received his PhD from school of medicine and pharmacy of Ocean University of China. His research interests include drug design, drug delivery, and molecule imaging for diagnosis and therapy. He has published over 40 peer-reviewed papers.
ISSN:2040-3364
2040-3372
DOI:10.1039/d2nr06056f