Dichloromethanol but not difluoromethanol as a viable surrogate of carbon monoxide for prodrug design

Herein, we demonstrate that dichloromethanol but not difluoromethanol is a viable surrogate of carbon monoxide for prodrug design. A proof of concept was established by the successful development of a ROS-responsive carbon monoxide prodrug, presenting specific CO release in response to endogenous RO...

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 59; no. 37; pp. 5583 - 5586
Main Authors Liu, Miao, Li, Zhang, Hu, Ziwei, Yan, ZhiCheng, Min, Qingqiang, Peng, Wei, Ji, Xingyue
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 04.05.2023
Royal Society of Chemistry
Subjects
Animals
Carbon Monoxide
Chemistry
Chemistry, Multidisciplinary
Mice
Physical Sciences
Prodrugs - pharmacology
RAW 264.7 Cells
Reactive Oxygen Species
Science & Technology
GASOTRANSMITTER PRODRUGS
METABOLISM
DONOR
DIHALOMETHANES
LIGHT
RELEASE
CO
MOLECULES
DELIVERY
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Summary:Herein, we demonstrate that dichloromethanol but not difluoromethanol is a viable surrogate of carbon monoxide for prodrug design. A proof of concept was established by the successful development of a ROS-responsive carbon monoxide prodrug, presenting specific CO release in response to endogenous ROS in cells. Herein, we demonstrate that dichloromethanol but not difluoromethanol is a viable surrogate of carbon monoxide for prodrug design.
Bibliography:https://doi.org/10.1039/d3cc01486j
Electronic supplementary information (ESI) available. See DOI
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1359-7345
1364-548X
DOI:10.1039/d3cc01486j