Evaluation of acetophenone monooxygenase and alcohol dehydrogenase activities in different fungal strains by biotransformation of acetophenone derivatives

Experimental conditions using whole cells to select fungal strains for specific bioreduction of ketones and formation of Baeyer–Villiger oxidation products were studied. Epicoccum nigrum SSP 1498 was effective in the bioreduction leading to the chiral alcohols in up to 98% enantiomeric excess. High...

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Published inJournal of molecular catalysis. B, Enzymatic Vol. 31; no. 4; pp. 129 - 135
Main Authors Andrade, Leandro H., Keppler, Artur F., Schoenlein-Crusius, Iracema H., Porto, André L.M., Comasseto, João V.
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier B.V 08.12.2004
Elsevier Science
Subjects
Baeyer–Villiger oxidation
Bioconversions. Hemisynthesis
Biological and medical sciences
Bioreduction
Biotechnology
Biotransformation
Dehydrogenase
Fundamental and applied biological sciences. Psychology
Fungus
Ketones
Methods. Procedures. Technologies
Monooxygenase
Phenols
Fungus
Baeyer–Villiger oxidation
Ketones
Biotransformation
Phenols
Bioreduction
Dehydrogenase
Monooxygenase
Baeyer-Villiger oxidation
Enzyme
Alcohol dehydrogenase
Ketone
Fungi
Baeyer Villiger reaction
Acetophenone derivatives
Oxidation
Oxidoreductases
Thallophyta
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Summary:Experimental conditions using whole cells to select fungal strains for specific bioreduction of ketones and formation of Baeyer–Villiger oxidation products were studied. Epicoccum nigrum SSP 1498 was effective in the bioreduction leading to the chiral alcohols in up to 98% enantiomeric excess. High acetophenone monooxygenase activity was observed by the use of the fungus Emericella nidulans CCT 3119 as biocatalyst.
ISSN:1381-1177
1873-3158
DOI:10.1016/j.molcatb.2004.08.006