Silver Sulfadiazine-Impregnated Hydrocolloid Dressing Is Beneficial in Split-Thickness Skin-Graft Donor Wound Healing in a Small Randomized Controlled Study

• Published in: International journal of lower extremity wounds Vol. 15; no. 4; p. 338
• Main Authors: Akita, Sadanori, Yoshimoto, Hiroshi, Tanaka, Katsuya, Oishi, Masao, Senju, Chikako, Mawatari, Seiji, Takahara, Eisaku, Suzuki, Sizuka, Hayashida, Kenji
• Format: Journal Article
• Language: English
• Published: United States 01.12.2016
• Subjects: Adult; Aged; Aged, 80 and over; Bandages; Bandages, Hydrocolloid; Female; Humans; Male; Middle Aged; Prospective Studies; Silver Sulfadiazine; Skin Transplantation; Sulfadiazine; Wound Healing; donor site wound; silver sulfadiazine–impregnated hydrocolloid dressing; quality of wound healing
• ISSN: 1552-6941
• DOI: 10.1177/1534734616670988

Donor-site wound healing was tested with a silver sulfadiazine (SSD)-impregnated hydrocolloid dressing and hydrocolloid dressing applied manually by a physician on site. A total of 14 patients, 5 woman and 9 men (23-89 years old, average = 61.6 ± 18.70 years), were enrolled in this prospective controlled study. The degree of bleeding was significantly less with the SSD-impregnated than with the hydrocolloid dressing (P < .01). In the moisture meter analysis, the values of the effective contact coefficient and corneal thickness were significantly smaller with the SSD-impregnated dressing (P < .05). In the color analysis, the clarity was significantly lower with the hydrocolloid dressing after 3 months than that of intact neighboring skin (P < .01). Regarding red-green color, SSD-impregnated and hydrocolloid values were significantly greater than the intact skin value immediately after and at 3 months, and the hydrocolloid value was significantly greater than intact at 6 months (P < .01 immediately; P < .01 at 3 months and intact at 6 months) in redness. Regarding yellow-blue color, the hydrocolloid value was significantly lower than the intact skin value at 3 months (P < .05 and intact) in yellow. The extensibility was significantly lower with the hydrocolloid dressing than in intact skin immediately (P < .01), and viscoelasticity was significantly lower with the hydrocolloid dressing than in intact skin immediately and after 3 and 6 months (P < .01 immediately and at 6 months and P < .05 at 3 months). The SSD-impregnated hydrocolloid dressing led to superior wound healing, decreased the degree of bleeding, and demonstrated better corneal barrier function, clarity, color matching, and viscoelasticity in split-thickness donors.