Association of Neutrophil/Lymphocyte Ratio With Intravenous Immunoglobulin Treatment in Children With Guillain-Barré Syndrome

Guillain-Barré syndrome (GBS) is an acute immune-mediated inflammatory polyneuropathy of the peripheral nervous system. The authors aimed to investigate whether the neutrophil/lymphocyte (N/L) and platelet/lymphocyte (P/L) ratios are the parameters that associated with the drug treatment or severity...

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Bibliographic Details
Published inJournal of child neurology Vol. 33; no. 2; p. 164
Main Authors Hüner, Ezgi Altuntas, Dai, Alper I, Demiryürek, Abdullah T
Format Journal Article
LanguageEnglish
Published United States 01.02.2018
Subjects
Biomarkers - blood
Child
Female
Guillain-Barre Syndrome - blood
Guillain-Barre Syndrome - immunology
Guillain-Barre Syndrome - therapy
Humans
Immunoglobulins, Intravenous - therapeutic use
Immunologic Factors - therapeutic use
Leukocyte Count
Lymphocytes - immunology
Male
Neutrophils - immunology
Retrospective Studies
Severity of Illness Index
Treatment Outcome
treatment
neuropathy
autoimmune
children
pediatric
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Summary:Guillain-Barré syndrome (GBS) is an acute immune-mediated inflammatory polyneuropathy of the peripheral nervous system. The authors aimed to investigate whether the neutrophil/lymphocyte (N/L) and platelet/lymphocyte (P/L) ratios are the parameters that associated with the drug treatment or severity of GBS. Twenty-seven children with GBS were retrospectively analyzed from the medical records of patients who attended to the Pediatric Neurology Department of the Gaziantep University Hospital. Biochemical and hematologic parameters were measured. Leukocytes, neutrophils counts and N/L ratio were significantly higher before the intravenous immunoglobulin treatment ( P < .001). However, there were no marked differences in platelet count and P/L ratio. In addition, marked correlation was observed between the N/L ratio after treatment and duration of weakness. The results of the study showed that N/L ratio is significantly higher in GBS patients, and reduces following with intravenous immunoglobulin treatment.
ISSN:1708-8283
DOI:10.1177/0883073817748109