Enantioselective fluorination of 3-indolinone-2-carboxylates with NFSI catalyzed by chiral bisoxazolines

A chiral Cu( i )-bisoxazoline complex catalyzed enantioselective electrophilic fluorination of 3-indolinone-2-carboxylates with NFSI has been accomplished to produce chiral 2-fluoro-3-indolinone-2-carboxylates in good yields with excellent enantioselectivities. This is the first report on the enanti...

Full description

Saved in:
Bibliographic Details
Published inOrganic & biomolecular chemistry Vol. 19; no. 27; pp. 685 - 691
Main Authors Banik, Swarnayu, Sahoo, Tanmoy, Sridhar, B, Subba Reddy, B. V
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 21.07.2021
Royal Society of Chemistry
Subjects
Carboxylates
Chemistry
Chemistry, Organic
Crystallography
Enantiomers
Fluorination
Physical Sciences
Science & Technology
ALPHA-FLUORINATION
MONO
BETA-KETO-ESTERS
Online AccessGet full text

Cover

More Information
Summary:A chiral Cu( i )-bisoxazoline complex catalyzed enantioselective electrophilic fluorination of 3-indolinone-2-carboxylates with NFSI has been accomplished to produce chiral 2-fluoro-3-indolinone-2-carboxylates in good yields with excellent enantioselectivities. This is the first report on the enantioselective fluorination of 2-substituted 3-indolinones using a chiral Cu( i )-bisoxazoline complex. A chiral Cu( i )-bisoxazoline catalyzed enantioselective fluorination of 3-indolinone-2-carboxylates with NFSI is reported to produce chiral 2-fluoro-3-indolinone-2-carboxylates.
Bibliography:Electronic supplementary information (ESI) available. CCDC
For ESI and crystallographic data in CIF or other electronic format see DOI
10.1039/d1ob00144b
2047903
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1477-0520
1477-0539
DOI:10.1039/d1ob00144b