Self-catalyzed tumor ferroptosis based on ferrocene conjugated reactive oxygen species generation and a responsive polymer

• Published in: Chemical communications (Cambridge, England) Vol. 58; no. 2; pp. 3294 - 3297
• Main Authors: Li, Jisi, Zong, Qingyu, Liu, Ye, Xiao, Xuan, Zhou, Jielian, Zhao, Zhongyi, Yuan, Youyong
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 08.03.2022
• Subjects: Catalysis; Cell Line, Tumor; Ferroptosis; Humans; Metallocenes; Neoplasms; Polymers; Reactive Oxygen Species; Tumors

In this work, we developed a ferroptosis self-catalyst, PTAF, exhibiting self-catalyzed ferroptosis for enhanced cancer therapy. Briefly, synergistic actions of self-catalyzed &z.rad;OH accumulation and GPX4 indirect inactivation based on the establishment of the ROS self-catalytic loop effectiv...