Self-catalyzed tumor ferroptosis based on ferrocene conjugated reactive oxygen species generation and a responsive polymer

In this work, we developed a ferroptosis self-catalyst, PTAF, exhibiting self-catalyzed ferroptosis for enhanced cancer therapy. Briefly, synergistic actions of self-catalyzed &z.rad;OH accumulation and GPX4 indirect inactivation based on the establishment of the ROS self-catalytic loop effectiv...

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Published inChemical communications (Cambridge, England) Vol. 58; no. 2; pp. 3294 - 3297
Main Authors Li, Jisi, Zong, Qingyu, Liu, Ye, Xiao, Xuan, Zhou, Jielian, Zhao, Zhongyi, Yuan, Youyong
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 08.03.2022
Subjects
Catalysis
Cell Line, Tumor
Ferroptosis
Humans
Metallocenes
Neoplasms
Polymers
Reactive Oxygen Species
Tumors
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Summary:In this work, we developed a ferroptosis self-catalyst, PTAF, exhibiting self-catalyzed ferroptosis for enhanced cancer therapy. Briefly, synergistic actions of self-catalyzed &z.rad;OH accumulation and GPX4 indirect inactivation based on the establishment of the ROS self-catalytic loop effectively induced tumor ferroptosis, which provided a novel approach for enhanced tumor therapy. In this work, PTAF functions as a ferroptosis self-catalyst, through synergistic actions of self-catalyzed &z.rad;OH accumulation and GPX4 indirect inactivation based on the ROS self-catalytic loop, effectively induced tumor ferroptosis.
Bibliography:Electronic supplementary information (ESI) available. See DOI
10.1039/d1cc06742g
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1359-7345
1364-548X
DOI:10.1039/d1cc06742g