Self-catalyzed tumor ferroptosis based on ferrocene conjugated reactive oxygen species generation and a responsive polymer
In this work, we developed a ferroptosis self-catalyst, PTAF, exhibiting self-catalyzed ferroptosis for enhanced cancer therapy. Briefly, synergistic actions of self-catalyzed &z.rad;OH accumulation and GPX4 indirect inactivation based on the establishment of the ROS self-catalytic loop effectiv...
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| Published in | Chemical communications (Cambridge, England) Vol. 58; no. 2; pp. 3294 - 3297 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Royal Society of Chemistry
08.03.2022
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| Abstract | In this work, we developed a ferroptosis self-catalyst, PTAF, exhibiting self-catalyzed ferroptosis for enhanced cancer therapy. Briefly, synergistic actions of self-catalyzed &z.rad;OH accumulation and GPX4 indirect inactivation based on the establishment of the ROS self-catalytic loop effectively induced tumor ferroptosis, which provided a novel approach for enhanced tumor therapy.
In this work, PTAF functions as a ferroptosis self-catalyst, through synergistic actions of self-catalyzed &z.rad;OH accumulation and GPX4 indirect inactivation based on the ROS self-catalytic loop, effectively induced tumor ferroptosis. |
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| AbstractList | In this work, we developed a ferroptosis self-catalyst, PTAF, exhibiting self-catalyzed ferroptosis for enhanced cancer therapy. Briefly, synergistic actions of self-catalyzed ˙OH accumulation and GPX4 indirect inactivation based on the establishment of the ROS self-catalytic loop effectively induced tumor ferroptosis, which provided a novel approach for enhanced tumor therapy. In this work, we developed a ferroptosis self-catalyst, PTAF, exhibiting self-catalyzed ferroptosis for enhanced cancer therapy. Briefly, synergistic actions of self-catalyzed ·OH accumulation and GPX4 indirect inactivation based on the establishment of the ROS self-catalytic loop effectively induced tumor ferroptosis, which provided a novel approach for enhanced tumor therapy. In this work, we developed a ferroptosis self-catalyst, PTAF, exhibiting self-catalyzed ferroptosis for enhanced cancer therapy. Briefly, synergistic actions of self-catalyzed &z.rad;OH accumulation and GPX4 indirect inactivation based on the establishment of the ROS self-catalytic loop effectively induced tumor ferroptosis, which provided a novel approach for enhanced tumor therapy. In this work, PTAF functions as a ferroptosis self-catalyst, through synergistic actions of self-catalyzed &z.rad;OH accumulation and GPX4 indirect inactivation based on the ROS self-catalytic loop, effectively induced tumor ferroptosis. |
| Author | Zhou, Jielian Liu, Ye Li, Jisi Xiao, Xuan Zhao, Zhongyi Yuan, Youyong Zong, Qingyu |
| AuthorAffiliation | Key Laboratory of Biomedical Engineering of Guangdong Province South China University of Technology School of Medicine National Engineering Research Center for Tissue Restoration and Reconstruction Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education and Innovation Center for Tissue Restoration and Reconstruction |
| AuthorAffiliation_xml | – name: School of Medicine – name: South China University of Technology – name: Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education and Innovation Center for Tissue Restoration and Reconstruction – name: National Engineering Research Center for Tissue Restoration and Reconstruction – name: Key Laboratory of Biomedical Engineering of Guangdong Province |
| Author_xml | – sequence: 1 givenname: Jisi surname: Li fullname: Li, Jisi – sequence: 2 givenname: Qingyu surname: Zong fullname: Zong, Qingyu – sequence: 3 givenname: Ye surname: Liu fullname: Liu, Ye – sequence: 4 givenname: Xuan surname: Xiao fullname: Xiao, Xuan – sequence: 5 givenname: Jielian surname: Zhou fullname: Zhou, Jielian – sequence: 6 givenname: Zhongyi surname: Zhao fullname: Zhao, Zhongyi – sequence: 7 givenname: Youyong surname: Yuan fullname: Yuan, Youyong |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35175251$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_dyepig_2022_110586 crossref_primary_10_1016_j_matdes_2023_112072 crossref_primary_10_1039_D3TB01887C crossref_primary_10_1016_j_ccr_2024_215732 crossref_primary_10_3389_fonc_2023_1222098 crossref_primary_10_1039_D4SC02002B crossref_primary_10_1093_rb_rbad004 |
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| Title | Self-catalyzed tumor ferroptosis based on ferrocene conjugated reactive oxygen species generation and a responsive polymer |
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