STEREOSELECTIVE SYNTHESIS OF N-BOC-O-BENZYL-(4S,5S)-5-AMINO-4-HYDROXY-6-PHENYLHEXANOIC ACID, THE HYDROXYETHYLENE ISOSTERIC MOIETY OF POTENT HIV-1 PROTEASE INHIBITOR

N-Boc-O-benzyl-(4S,5S)-5-amino-4-hydroxy-6-phenylhexanoic acid is synthesized in a highly stereoselective way involving, as a key step, regioselective opening of carbohydrate-based aziridine ring.

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Bibliographic Details
Published inTetrahedron letters Vol. 32; no. 16; pp. 1897 - 1898
Main Authors CHAKRABORTY, TK, GANGAKHEDKAR, KK
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 15.04.1991
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
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Summary:N-Boc-O-benzyl-(4S,5S)-5-amino-4-hydroxy-6-phenylhexanoic acid is synthesized in a highly stereoselective way involving, as a key step, regioselective opening of carbohydrate-based aziridine ring.
ISSN:0040-4039
DOI:10.1016/S0040-4039(00)85991-2