Structural elucidation, total synthesis, and cytotoxic activity of effphenol A
A highly substituted phenol derivative, effphenol A ( 1 ), was isolated from the deep-sea-derived fungus Trichobotrys effuse FS524. Its complete structural assignment was established through a combination of spectroscopic analysis together with single-crystal X-ray diffraction experiments and furthe...
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Published in | Organic & biomolecular chemistry Vol. 18; no. 44; pp. 935 - 938 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
CAMBRIDGE
Royal Soc Chemistry
28.11.2020
Royal Society of Chemistry |
Subjects | |
Online Access | Get full text |
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Summary: | A highly substituted phenol derivative, effphenol A (
1
), was isolated from the deep-sea-derived fungus
Trichobotrys effuse
FS524. Its complete structural assignment was established through a combination of spectroscopic analysis together with single-crystal X-ray diffraction experiments and further unequivocally confirmed by a biomimetic total synthesis. Structurally, effphenol A possesses a poly-substituted 6-5/6/6 tetracyclic ring system, which represents the first case of such a skeleton found in nature. Furthermore, the cytotoxic activity of effphenol A (
1
) toward four human cancer cell lines was assayed.
Effphenol A was isolated and elucidated through spectroscopic analysis together with single-crystal X-ray diffraction experiments and further confirmed by the first biomimetic total synthesis. |
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Bibliography: | For ESI and crystallographic data in CIF or other electronic format see DOI 1974672 10.1039/d0ob01985b Electronic supplementary information (ESI) available: Experimental details, including procedures, syntheses, and the characterization of new products; 1D and 2D NMR, UV, HRESI, as well as a CIF file. CCDC ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1477-0520 1477-0539 1477-0539 |
DOI: | 10.1039/d0ob01985b |