Electrochemical thiocyanation of barbituric acids
The electrochemical thiocyanation of barbituric acids with NH 4 SCN was disclosed in an undivided cell under constant current conditions. The electrosynthesis is the most efficient at a record high current density ( j anode 50-70 mA cm −2 ). NH 4 SCN has a dual role as the source of the SCN group an...
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Published in | Organic & biomolecular chemistry Vol. 2; no. 17; pp. 3629 - 3636 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
CAMBRIDGE
Royal Soc Chemistry
04.05.2022
Royal Society of Chemistry |
Subjects | |
Online Access | Get full text |
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Summary: | The electrochemical thiocyanation of barbituric acids with NH
4
SCN was disclosed in an undivided cell under constant current conditions. The electrosynthesis is the most efficient at a record high current density (
j
anode
50-70 mA cm
−2
). NH
4
SCN has a dual role as the source of the SCN group and as the electrolyte. Electrochemical thiocyanation of barbituric acids starts with the generation of (SCN)
2
from the thiocyanate anion. The addition of thiocyanogen to the double bond of the enol tautomer of barbituric acid gives thiocyanated barbituric acid. A variety of thiocyanated barbituric acids bearing different functional groups were obtained in 18-95% yields and were shown to exhibit promising antifungal activity.
The electrochemical thiocyanation of barbituric acids with NH
4
SCN in an undivided cell at a record high current density was disclosed. |
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Bibliography: | https://doi.org/10.1039/d2ob00343k Electronic supplementary information (ESI) available. See DOI Russian Science Foundation ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
ISSN: | 1477-0520 1477-0539 1477-0539 |
DOI: | 10.1039/d2ob00343k |