Electrochemical thiocyanation of barbituric acids

The electrochemical thiocyanation of barbituric acids with NH 4 SCN was disclosed in an undivided cell under constant current conditions. The electrosynthesis is the most efficient at a record high current density ( j anode 50-70 mA cm −2 ). NH 4 SCN has a dual role as the source of the SCN group an...

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Published inOrganic & biomolecular chemistry Vol. 2; no. 17; pp. 3629 - 3636
Main Authors Bityukov, Oleg V, Kirillov, Andrey S, Serdyuchenko, Pavel Yu, Kuznetsova, Maria A, Demidova, Valentina N, Vil', Vera A, Terent'ev, Alexander O
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 04.05.2022
Royal Society of Chemistry
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Summary:The electrochemical thiocyanation of barbituric acids with NH 4 SCN was disclosed in an undivided cell under constant current conditions. The electrosynthesis is the most efficient at a record high current density ( j anode 50-70 mA cm −2 ). NH 4 SCN has a dual role as the source of the SCN group and as the electrolyte. Electrochemical thiocyanation of barbituric acids starts with the generation of (SCN) 2 from the thiocyanate anion. The addition of thiocyanogen to the double bond of the enol tautomer of barbituric acid gives thiocyanated barbituric acid. A variety of thiocyanated barbituric acids bearing different functional groups were obtained in 18-95% yields and were shown to exhibit promising antifungal activity. The electrochemical thiocyanation of barbituric acids with NH 4 SCN in an undivided cell at a record high current density was disclosed.
Bibliography:https://doi.org/10.1039/d2ob00343k
Electronic supplementary information (ESI) available. See DOI
Russian Science Foundation
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SourceType-Scholarly Journals-1
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ISSN:1477-0520
1477-0539
1477-0539
DOI:10.1039/d2ob00343k