Mn() complex impregnated porous silica nanoparticles as Zn()-responsive "Smart" MRI contrast agent for pancreas imaging
Type-1 and type-2 diabetes mellitus are metabolic disorders governed by the functional efficiency of pancreatic β-cells. The activities of the cells toward insulin production, storage, and secretion are accompanied by Zn( ii ) ions. Thus, for non-invasive pathology of the cell, developing Zn( ii ) i...
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Published in | Journal of materials chemistry. B, Materials for biology and medicine Vol. 11; no. 34; pp. 8251 - 8261 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Royal Society of Chemistry
30.08.2023
|
Subjects | |
Online Access | Get full text |
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Summary: | Type-1 and type-2 diabetes mellitus are metabolic disorders governed by the functional efficiency of pancreatic β-cells. The activities of the cells toward insulin production, storage, and secretion are accompanied by Zn(
ii
) ions. Thus, for non-invasive pathology of the cell, developing Zn(
ii
) ion-responsive MRI-contrast agents has earned considerable interest. In this report, we have synthesized a seven-coordinate, mono(aquated) Mn(
ii
) complex (
1
), which is impregnated within a porous silica nanosphere of size 13.2 nm to engender the Mn(
ii
)-based MRI contrast agent, complex
1
@SiO
2
NP. The surface functionalization of the nanosphere by the Py
2
Pic organic moiety for the selective binding of Zn(
ii
)-ions yields complex
1
@SiO
2
-Py
2
PicNP, which exhibits
r
1
= 13.19 mM
−1
s
−1
. The relaxivity value elevates to 20.38 mM
−1
s
−1
in the presence of 0.6 mM BSA protein at pH 7.4. Gratifyingly,
r
1
increases linearly with the increase of Zn(
ii
) ion concentration and reaches 39.01 mM
−1
s
−1
in the presence of a 40 fold excess of the ions. Thus, Zn(
ii
)-responsive contrast enhancement
in vivo
is envisaged by employing the nanoparticle. Indeed, a contrast enhancement in the pancreas is observed when complex
1
@SiO
2
-Py
2
PicNP and a glucose stimulus are administered in fasted healthy C57BL/6 mice at 7 T.
Mn(
ii
)-based porous silica nanoparticle encapsulated Zn(
ii
)-responsive MRI contrast agent has been investigated to examine the pathological condition of pancreatic β-cells whose functional efficiency is related to type-1 and type-2 diabetes mellitus. |
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Bibliography: | Electronic supplementary information (ESI) available. CCDC For ESI and crystallographic data in CIF or other electronic format see DOI https://doi.org/10.1039/d3tb01289a 2260190 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 2050-750X 2050-7518 |
DOI: | 10.1039/d3tb01289a |