A triphenylphosphine coordinated Cu() Fenton-like agent with ferrocene moieties for enhanced chemodynamic therapy
A triphenylphosphine coordinated Cu( i ) complex of Fc-OD-Cu was rationally designed for chemodynamic therapy (CDT) of cancer. The complex was capable of generating a highly toxic hydroxyl radical (&z.rad;OH) via a Fenton-like reaction induced by Cu( i ) moieties and simultaneously mediated by f...
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| Published in | Dalton transactions : an international journal of inorganic chemistry Vol. 51; no. 47; pp. 1854 - 1858 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Royal Society of Chemistry
06.12.2022
|
| Subjects | |
| Online Access | Get full text |
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| Summary: | A triphenylphosphine coordinated Cu(
i
) complex of
Fc-OD-Cu
was rationally designed for chemodynamic therapy (CDT) of cancer. The complex was capable of generating a highly toxic hydroxyl radical (&z.rad;OH)
via
a Fenton-like reaction induced by Cu(
i
) moieties and simultaneously mediated by ferrocene moieties. As a result, the CDT efficiency of
Fc-OD-Cu
is higher than that of
Ba-OD-Cu
(without ferrocene moieties) and
Fc-OD
(without Cu(
i
) moieties).
A Triphenylphilosophy Coordinated Cu (
i
) CDT Agent (
Fc OD Cu
) with Ferrocene Moieties was rationally constructed, its CDT efficiency is higher than that of
Ba OD Cu
(without ferrocene moods) and
Fc OD
(without Cu (
i
) moods). |
|---|---|
| Bibliography: | Electronic supplementary information (ESI) available. CCDC https://doi.org/10.1039/d2dt03088h For ESI and crystallographic data in CIF or other electronic format see DOI 2205234 2205233 and |
| ISSN: | 1477-9226 1477-9234 |
| DOI: | 10.1039/d2dt03088h |