Long-term follow-up of Dupuytren disease after injection of triamcinolone acetonide in Chinese patients in Taiwan

• Published in: The Journal of hand surgery, European volume Vol. 42; no. 7; p. 678
• Main Authors: Yin, C-Y, Yu, H-H M, Wang, J-P, Huang, Y-C, Huang, T-F, Chang, M-C
• Format: Journal Article
• Language: English
• Published: England 01.09.2017
• Subjects: Aged; Aged, 80 and over; Asian Continental Ancestry Group; Disease Progression; Dupuytren Contracture - diagnostic imaging; Dupuytren Contracture - drug therapy; Dupuytren Contracture - ethnology; Female; Follow-Up Studies; Glucocorticoids - administration & dosage; Humans; Injections, Intralesional; Male; Middle Aged; Taiwan; Triamcinolone Acetonide - administration & dosage; Ultrasonography; triamcinolone acetonide; ethnicity; Dupuytren’s disease; ultrasound
• ISSN: 2043-6289
• DOI: 10.1177/1753193417690961

Injection of triamcinolone acetonide is a non-operative treatment for early-stage Dupuytren disease in Caucasians, but its effectiveness in non-Caucasians is unclear. We report averaged 5-year follow-up results of 37 patients (49 affected hands) with early-stage Dupuytren disease for patients in Taiwan (non-Caucasian) who received a single dose of 5 mg triamcinolone acetonide injection into nodules monthly for 3 months. Using ultrasound, we recorded no progression of sizes of the modules following injection after 6 months. After an average 5-year follow-up, two patients with three hands (6%) experienced reactivation of the treated nodules. None required surgical intervention. Ultrasound examination showed that sizes of the treated Dupuytren nodules decreased significantly by 40% 6 months after injection and 56% at the final follow-up. We conclude that in these Chinese patients in Taiwan with early Dupuytren nodules, triamcinolone acetonide injection was effective in reducing the size of the Dupuytren nodules and maintaining long-term durable control of the nodular growth. III.