Aβ aggregation behavior at interfaces with switchable wettability: a bioinspired perspective to understand amyloid formation

An amphiphilic taurocholic acid (TCA) doped polypyrrole (PPy) film (PPy/TCA) was used as a dynamic mimic membrane model to explore how switchable surface wettability influences amyloid aggregation. Our results indicate that the hydrophobic surface, not the hydrophilic surface, plays important roles...

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Published inChemical communications (Cambridge, England) Vol. 57; no. 21; pp. 2641 - 2644
Main Authors Guan, Yijia, Yu, Dongqin, Sun, Hanjun, Ren, Jinsong, Qu, Xiaogang
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 11.03.2021
Subjects
Agglomeration
Biomimetics
Polypyrroles
Wettability
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Summary:An amphiphilic taurocholic acid (TCA) doped polypyrrole (PPy) film (PPy/TCA) was used as a dynamic mimic membrane model to explore how switchable surface wettability influences amyloid aggregation. Our results indicate that the hydrophobic surface, not the hydrophilic surface, plays important roles in Aβ40 adsorption and aggregation. A PPy/TCA film was used as a model to show that the effect of dynamic wettability strongly influences amyloid formation.
Bibliography:10.1039/d0cc07546a
Electronic supplementary information (ESI) available: See DOI
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1359-7345
1364-548X
DOI:10.1039/d0cc07546a