Pediatric hemiplegic migraine: Role of multiple MRI techniques in evaluation of reversible hypoperfusion

• Published in: Cephalalgia Vol. 34; no. 4; pp. 311 - 315
• Main Authors: Bosemani, Thangamadhan, Burton, Vera J, Felling, Ryan J, Leigh, Richard, Oakley, Christopher, Poretti, Andrea, Huisman, Thierry AGM
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.04.2014
• Subjects: Adolescent; Diffusion Tensor Imaging; Female; Hemiplegia - etiology; Hemiplegia - pathology; Humans; Image Interpretation, Computer-Assisted; Magnetic Resonance Imaging - methods; Migraine with Aura - pathology; perfusion-weighted imaging; hemiplegic migraine; Susceptibility weighted imaging; children; neuroimaging
• ISSN: 0333-1024; 1468-2982
• DOI: 10.1177/0333102413509432

Background Hemiplegic migraine (HM) is a rare type of migraine with aura that involves motor weakness. Data on conventional and advanced neuroimaging findings during prolonged attacks of HM are limited, particularly in children. Case A 13-year-old-female with a history of migraine had a typical attack of HM characterized by right-sided hemiplegia, deterioration of vigilance and paraphasia. MRI performed 3 hours after hemiplegia onset revealed normal diffusion tensor imaging (DTI) sequences, but perfusion weighted imaging (PWI) showed a large area of hypoperfusion within the left cerebral hemisphere and susceptibility weighted imaging (SWI) demonstrated a matching area with prominent, hypointense draining sulcal veins. Magnetic resonance angiography (MRA) revealed subtle narrowing of the left middle cerebral artery. The neuroimaging abnormalities completely resolved 24 hours after the attack onset. Conclusion Multiple conventional and advanced MRI techniques including SWI play a key role in an HM attack to (1) exclude acute arterial ischemic stroke and (2) further understand the pathophysiology of HM.