In silico drug screen in mouse liver identifies candidate calorie restriction mimetics

Calorie restriction (CR) extends life span in mammals and delays the onset of age-related diseases, including cancer and diabetes. Drugs that target the same genes and pathways as CR may have enormous therapeutic potential. Recently, genome-scale data on the responses of human cell lines to over 1,0...

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Bibliographic Details
Published inRejuvenation research Vol. 15; no. 2; p. 148
Main Authors Fortney, Kristen, Morgen, Eric K, Kotlyar, Max, Jurisica, Igor
Format Journal Article
LanguageEnglish
Published United States 01.04.2012
Subjects
Animals
Caloric Restriction - methods
Cell Line
Chromosome Mapping
Computational Biology - methods
Drug Evaluation, Preclinical
Gene Expression Regulation
Genome
Genome, Human
Humans
Liver - drug effects
Liver - metabolism
Mice
Oligonucleotide Array Sequence Analysis
Software
Transcription, Genetic
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Summary:Calorie restriction (CR) extends life span in mammals and delays the onset of age-related diseases, including cancer and diabetes. Drugs that target the same genes and pathways as CR may have enormous therapeutic potential. Recently, genome-scale data on the responses of human cell lines to over 1,000 drug treatments have become available. Here we integrate these data with gene expression signatures of CR in mouse liver to generate a prioritized list of candidate CR mimetics. We identify 14 drugs that reproduce the effects of CR at the transcriptional level.
ISSN:1557-8577
DOI:10.1089/rej.2011.1263