A highly selective ratio-metric fluorescent sensor for visualizing nitroreductase in hypoxic cells

Herein, we have developed a novel single-molecular probe (NORP) for selective and accurate determination of NTR in living cells. It was discovered that up-regulation of endogenous NTR occurred in response to hypoxic stimulation, and there was a dependence between the NTR levels and the degree of hyp...

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 6; no. 1; pp. 83 - 86
Main Authors Xu, Yumei, Hu, Bing, Cui, Yanjun, Li, Li, Nian, Fang, Zhang, Zhixia, Wang, Wenting
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 19.12.2023
Royal Society of Chemistry
Subjects
Chemistry
Chemistry, Multidisciplinary
Fluorescence
Hypoxia
Physical Sciences
Science & Technology
PROBE
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Summary:Herein, we have developed a novel single-molecular probe (NORP) for selective and accurate determination of NTR in living cells. It was discovered that up-regulation of endogenous NTR occurred in response to hypoxic stimulation, and there was a dependence between the NTR levels and the degree of hypoxia. An accurate and selective ratio-metric fluorescent sensor for visualizing nitroreductase in hypoxic cells.
Bibliography:https://doi.org/10.1039/d3cc05063g
NORP
photophysical properties and biocompatibility. See DOI
Electronic supplementary information (ESI) available: NMR and MS spectra of
ObjectType-Article-1
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content type line 23
ISSN:1359-7345
1364-548X
DOI:10.1039/d3cc05063g