Immunoadjuvant-functionalized metal-organic frameworks: synthesis and applications in tumor immune modulation
Cancer immunotherapy, which leverages the body's immune system to recognize and attack cancer cells, has made significant progress, particularly in the treatment of metastatic tumors. However, challenges such as drug stability and off-target effects still limit its clinical success. To address...
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| Published in | Chemical communications (Cambridge, England) Vol. 61; no. 1; pp. 1962 - 1977 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Royal Society of Chemistry
28.01.2025
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Cancer immunotherapy, which leverages the body's immune system to recognize and attack cancer cells, has made significant progress, particularly in the treatment of metastatic tumors. However, challenges such as drug stability and off-target effects still limit its clinical success. To address these issues, metal-organic frameworks (MOFs) have emerged as promising nanocarriers in cancer immunotherapy. MOFs have unique porous structure, excellent drug loading capacity, and tunable surface modification properties. MOFs not only enhance drug delivery efficiency but also allow for precise control of drug release. They reduce off-target effects and significantly improve targeting and therapy efficacy. As research deepens, MOFs' effectiveness as drug carriers has been refined. When combined with immunoadjuvants or anticancer drugs, MOFs further stimulate the immune response. This improves the specificity of immune attacks on tumors. This review provides a comprehensive overview of the applications of MOFs in cancer immunotherapy. It focuses on synthesis, drug loading strategies, and surface modifications. It also analyzes their role in enhancing immunotherapy effectiveness. By integrating current research, we aim to provide insights for the future development of immunoadjuvant-functionalized MOFs, accelerating their clinical application for safer and more effective cancer treatments.
This review explores the synthesis, drug loading, and surface modifications of metal-organic frameworks (MOFs), highlighting their role in improving cancer immunotherapy and paving the way for safer and more effective treatments. |
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| Bibliography: | Zhenqi Jiang received his PhD degree at Ningbo Institute of Materials Technology & Engineering, CAS. Now, he is an assistant professor at the School of Medical Technology, Beijing Institute of Technology. His research interests include biomedical engineering and materials science. Xiaoying Tang is a professor at School of Medical Technology, Beijing Institute of Technology. She is mainly engaged in scientific research and teaching in the fields of biomedical engineering and communication and information systems, and has in-depth research in biomedical signal detection and processing, medical image processing, and key technologies of magnetic resonance imaging (MRI) equipment. Jianing Wang is currently an undergraduate student in the School of Medical Technology, the Qiushi College, Beijing Institute of Technology. He majors in biomedical engineering. His research interest is fabrication and application of biomedical materials. Chen Zhao received her master's degree at Ningbo Institute of Materials Technology & Engineering, CAS. Currently, she is studying for a PhD in the School of Medical Technology, Beijing Institute of Technology. Her research interests include biomedical engineering and material science. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 |
| ISSN: | 1359-7345 1364-548X 1364-548X |
| DOI: | 10.1039/d4cc06510g |