Synthesis, characterization and biological evaluation of poly [LA-co-(Glc-alt-Lys)] for nerve regeneration scaffold
A novel nerve repairing material poly [LA-co-(Glc-alt-Lys)] (PLGL) was synthesized. The viability and growth of Schwann cells (SCs) co-cultured with poly (D, L-lactic acid) (PDLLA) films (control group) and PLGL films were evaluated by MTT assay and SEM observation. Then, contact angle measurement,...
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| Published in | Frontiers of materials science Vol. 8; no. 1; pp. 95 - 101 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
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Heidelberg
Higher Education Press
01.03.2014
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| Abstract | A novel nerve repairing material poly [LA-co-(Glc-alt-Lys)] (PLGL) was synthesized. The viability and growth of Schwann cells (SCs) co-cultured with poly (D, L-lactic acid) (PDLLA) films (control group) and PLGL films were evaluated by MTT assay and SEM observation. Then, contact angle measurement, histological assessment and enzyme-linked immunosorbent assay (ELISA) testing on inflammatory-related cytokines such as IL-10 and TGF-β1 were performed. The results showed that, compared with PDLLA, PLGL films possesses better hydrophilicity, biocompatibility, degradation property and less inflammatory reaction. The present study indicated that PLGL scaffolds would meet the requirements of artificial nerve scaffold and have a potential application in the fields of nerve regeneration. |
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| AbstractList | A novel nerve repairing material poly [LA-co-(Glc-alt-Lys)] (PLGL) was synthesized. The viability and growth of Schwann cells (SCs) co-cultured with poly (D, Llactic acid) (PDLLA) films (control group) and PLGL films were evaluated by MTTassay and SEM observation. Then, contact angle measurement, histological assessment and enzyme-linked immunosorbent assay (ELISA) testing on inflammatory-related cytokines such as IL-10 and TGF-β1 were performed. The results showed that, compared with PDLLA, PLGL films possesses better hydrophilicity, biocompatibility, degradation property and less inflammatory reaction. The present study indicated that PLGL scaffolds would meet the requirements of artificial nerve scaffold and have a potential application in the fields of nerve regeneration. A novel nerve repairing material poly [LA-co-(Glc-alt-Lys)] (PLGL) was synthesized. The viability and growth of Schwann cells (SCs) co-cultured with poly (D, L-lactic acid) (PDLLA) films (control group) and PLGL films were evaluated by MTT assay and SEM observation. Then, contact angle measurement, histological assessment and enzyme-linked immunosorbent assay (ELISA) testing on inflammatory-related cytokines such as IL-10 and TGF-β1 were performed. The results showed that, compared with PDLLA, PLGL films possesses better hydrophilicity, biocompatibility, degradation property and less inflammatory reaction. The present study indicated that PLGL scaffolds would meet the requirements of artificial nerve scaffold and have a potential application in the fields of nerve regeneration. |
| Author | YIN, Yi-Xia YI, Ji-Ling DAI, Hong-Lian YAN, Qiong-Jiao LI, Shi-Pu XIE, Li-Juan |
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| Cites_doi | 10.1016/j.biomaterials.2014.02.012 10.1007/978-1-62703-444-9_9 10.1016/j.biomaterials.2003.09.052 10.1007/978-1-59745-133-8_8 10.1097/MAT.0000000000000044 10.1016/j.biocel.2013.12.008 10.1038/ni.1659 10.1016/j.nbt.2014.01.002 10.1007/978-1-4939-0345-0_29 10.1016/S0165-5728(99)00154-X 10.1111/j.1529-8027.2007.00148.x 10.1038/ni.1677 10.1007/s12015-012-9387-2 10.1016/j.biomaterials.2014.02.015 10.1038/nature06878 10.1002/glia.20970 |
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| Keywords | implantation inflammatory factor Schwann cell (SC) biocompatibility poly [LA-co-(Glc-alt-Lys)] (PLGL) |
| Language | English |
| License | This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. http://www.springer.com/tdm |
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| Notes | Document accepted on :2014-03-12 implantation inflammatory factor Schwann cell (SC) biocompatibility Document received on :2014-02-15 poly [LA-co-(Glc-alt-Lys)] (PLGL) |
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| Snippet | A novel nerve repairing material poly [LA-co-(Glc-alt-Lys)] (PLGL) was synthesized. The viability and growth of Schwann cells (SCs) co-cultured with poly (D,... |
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| SubjectTerms | biocompatibility Chemistry and Materials Science implantation inflammatory factor Materials Science poly [LA-co-(Glc-alt-Lys)] (PLGL) Research Article Schwann cell (SC) |
| Title | Synthesis, characterization and biological evaluation of poly [LA-co-(Glc-alt-Lys)] for nerve regeneration scaffold |
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