Synthesis, characterization and biological evaluation of poly [LA-co-(Glc-alt-Lys)] for nerve regeneration scaffold

• Published in: Frontiers of materials science Vol. 8; no. 1; pp. 95 - 101
• Main Authors: YIN, Yi-Xia, YI, Ji-Ling, XIE, Li-Juan, YAN, Qiong-Jiao, DAI, Hong-Lian, LI, Shi-Pu
• Format: Journal Article
• Language: English
• Published: Heidelberg Higher Education Press 01.03.2014
• Subjects: biocompatibility; Chemistry and Materials Science; implantation; inflammatory factor; Materials Science; poly [LA-co-(Glc-alt-Lys)] (PLGL); Research Article; Schwann cell (SC); implantation; inflammatory factor; Schwann cell (SC); biocompatibility; poly [LA-co-(Glc-alt-Lys)] (PLGL)
• ISSN: 2095-025X; 2095-0268
• DOI: 10.1007/s11706-014-0239-7

A novel nerve repairing material poly [LA-co-(Glc-alt-Lys)] (PLGL) was synthesized. The viability and growth of Schwann cells (SCs) co-cultured with poly (D, L-lactic acid) (PDLLA) films (control group) and PLGL films were evaluated by MTT assay and SEM observation. Then, contact angle measurement, histological assessment and enzyme-linked immunosorbent assay (ELISA) testing on inflammatory-related cytokines such as IL-10 and TGF-β1 were performed. The results showed that, compared with PDLLA, PLGL films possesses better hydrophilicity, biocompatibility, degradation property and less inflammatory reaction. The present study indicated that PLGL scaffolds would meet the requirements of artificial nerve scaffold and have a potential application in the fields of nerve regeneration.