Effects of estradiol and prolactin on growth of rat mammary adenocarcinoma cells in monolayer cultures

The effects of estradiol and ovine prolactin on the growth of a rat mammary adenocarcinoma cell line were investigated. The action of estradiol was dose-dependent. At less than or equal to 1 mug/ml it did not influence growth, at 5-10 mug/ml it was inhibitory, and at 20 mug/ml it was toxic. Prolacti...

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Bibliographic Details
Published inProceedings of the Society for Experimental Biology and Medicine Vol. 151; no. 2; p. 362
Main Authors Chan, P C, Tsuang, J, Head, J, Cohen, L A, Weisburger, J H
Format Journal Article
LanguageEnglish
Published United States 01.02.1976
Subjects
Adenocarcinoma - pathology
Animals
Cell Division - drug effects
Cells, Cultured
Dose-Response Relationship, Drug
Drug Interactions
Estradiol - pharmacology
Mammary Neoplasms, Experimental - pathology
Prolactin - pharmacology
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Summary:The effects of estradiol and ovine prolactin on the growth of a rat mammary adenocarcinoma cell line were investigated. The action of estradiol was dose-dependent. At less than or equal to 1 mug/ml it did not influence growth, at 5-10 mug/ml it was inhibitory, and at 20 mug/ml it was toxic. Prolactin alone had little effect on growth. However, the inhibitory effect of estradiol could be counteracted by a high concentration of prolactin. It appears, therefore, that the growth of cultured rat mammary adenocarcinoma cells can be regulated by the ratio of prolactin to estradiol: When the ratio is high growth is favored; when it is low, growth is inhibited.
ISSN:0037-9727
1525-1373
DOI:10.3181/00379727-151-39210