Biocompatible ruthenium polypyridyl complexes as efficient radiosensitizers

A biocompatible ruthenium polypyridyl complex has been rationally designed and synthesized, which self-assembles into nanoparticles in aqueous solution to enhance the water solubility and biocompatibility. When activated by X-rays, the nanostructure synergistically triggers ROS overproduction in can...

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Published inDalton transactions : an international journal of inorganic chemistry Vol. 48; no. 13; pp. 4114 - 4118
Main Authors Xiong, Zushuang, Zhong, Jing-Xiang, Zhao, Zhennan, Chen, Tianfeng
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 26.03.2019
Subjects
Aqueous solutions
Biocompatibility
Cell cycle
Nanoparticles
Radiation therapy
Radiosensitizers
Ruthenium
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Summary:A biocompatible ruthenium polypyridyl complex has been rationally designed and synthesized, which self-assembles into nanoparticles in aqueous solution to enhance the water solubility and biocompatibility. When activated by X-rays, the nanostructure synergistically triggers ROS overproduction in cancer cells to induce mitochondrial dysfunction and cell cycle arrest, thus realizing simultaneous chemo-radiotherapy. A biocompatible ruthenium polypyridyl complex has been rationally designed, which could self-assemble into nanoparticles in aqueous solution to enhance the solubility and biocompatibility, and could synergistically realize simultaneous cancer chemo-radiotherapy.
Bibliography:10.1039/c9dt00333a
Electronic supplementary information (ESI) available. See DOI
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SourceType-Scholarly Journals-1
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ISSN:1477-9226
1477-9234
1477-9234
DOI:10.1039/c9dt00333a