A protein inhibitor of hepatic drug metabolizing enzymes from Ehrlich ascites cells
Hepatic drug metabolizing enzymes were significantly decreased in Ehrlich ascites tumour-bearing mice. A protein inhibitor of hepatic drug metabolizing enzymes was isolated from Ehrlich ascites cells and purified. This involved ammonium sulphate fractionation (60–80%), DEAE, phosphocellulose, Sephad...
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Published in | Cancer letters Vol. 113; no. 1; pp. 1 - 8 |
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Main Author | |
Format | Journal Article |
Language | English |
Published |
Shannon
Elsevier Ireland Ltd
26.02.1997
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | Hepatic drug metabolizing enzymes were significantly decreased in Ehrlich ascites tumour-bearing mice. A protein inhibitor of hepatic drug metabolizing enzymes was isolated from Ehrlich ascites cells and purified. This involved ammonium sulphate fractionation (60–80%), DEAE, phosphocellulose, Sephadex G-100 and hydroxyapatite column chromatography. Purification attained was 800-fold. The inhibitory protein was effective in decreasing all the components of hepatic mixed-functionoxidase system and drug metabolizing enzymes both in vivo and in vitro. This novel inhibitor may have potential applications in chemical carcinogenesis. |
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ISSN: | 0304-3835 1872-7980 |
DOI: | 10.1016/S0304-3835(96)04536-3 |