Microwave-assisted synthesis of mGluR1 ligands: carbon, nitrogen and oxygen linked derivatives of pyrido[3,4- d]pyrimidin-4-ylamines

The syntheses of 6-fluoropyrido[3,4- d]pyrimidin-4-ylamine derivatives is reported herein. Methods for generating C, N and O linked analogues under microwave irradiation are described.

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Bibliographic Details
Published inTetrahedron letters Vol. 48; no. 24; pp. 4293 - 4296
Main Authors Harbottle, Gareth W., Feeder, Neil, Gibson, Karl R., Glossop, Mel, Maw, Graham N., Million, William A., Morel, Florence F., Osborne, Simon, Poinsard, Cedric
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 11.06.2007
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
ORGANIC-SYNTHESIS
NITROETHANE
ALKYLATION
PYRIDAZINES
HYDROAMINATION
RECEPTORS
NITROMETHANE
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Summary:The syntheses of 6-fluoropyrido[3,4- d]pyrimidin-4-ylamine derivatives is reported herein. Methods for generating C, N and O linked analogues under microwave irradiation are described.
Bibliography:ObjectType-Article-1
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content type line 23
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2007.04.035