Complexity of lower extremity peripheral artery disease reflects the complexity of coronary artery disease

• Published in: Vascular Vol. 23; no. 4; p. 366
• Main Authors: Aykan, Ahmet Çağrı, Hatem, Engin, Karabay, Can Yücel, Gül, İlker, Gökdeniz, Tayyar, Kalaycıoğlu, Ezgi, Turan, Turhan, Kara, Faruk, Arslan, Ahmet Oğuz, Dursun, İhsan, Çetin, Mustafa, Güler, Ahmet
• Format: Journal Article
• Language: English
• Published: England 01.08.2015
• Subjects: Aged; Biomarkers - blood; Chi-Square Distribution; Coronary Angiography; Coronary Artery Disease - blood; Coronary Artery Disease - diagnosis; Coronary Artery Disease - diagnostic imaging; Creatinine - blood; Cross-Sectional Studies; Female; Humans; Lipoproteins, HDL - blood; Lipoproteins, LDL - blood; Lower Extremity - blood supply; Male; Middle Aged; Multivariate Analysis; Peripheral Arterial Disease - blood; Peripheral Arterial Disease - classification; Peripheral Arterial Disease - diagnosis; Peripheral Arterial Disease - diagnostic imaging; Predictive Value of Tests; Retrospective Studies; Risk Factors; Severity of Illness Index; Sex Factors; Trans Atlantic Inter-Society Consensus; Peripheral; coronary; artery; SYNTAX; angiography
• ISSN: 1708-539X
• DOI: 10.1177/1708538114550738

We investigated the relationship between peripheral artery disease complexity and coronary artery disease complexity in patients with peripheral artery disease. A total of 449 patients were enrolled. SYNTAX score, a marker of coronary artery disease complexity, was assessed by dedicated computer software and complexity of peripheral artery disease was determined by Trans Atlantic Inter-Society Consensus II classification. The SYNTAX score of patients with minimal peripheral artery disease, Trans Atlantic Inter-Society Consensus A, Trans Atlantic Inter-Society Consensus B, Trans Atlantic Inter-Society Consensus C and Trans Atlantic Inter-Society Consensus D were 5 (11), 12.5 (13.25), 20 (14), 20.5 (19) and 27.5 (19), respectively (values in brackets represent the interquartile range). SYNTAX score and Trans Atlantic Inter-Society Consensus class was moderately correlated (r = 0.495, p < 0.001). In multivariate regression analysis male sex (B = 0.169, p < 0.001, CI95% = 0.270-0.735), Log10 SYNTAX score (B = 0.282, p < 0.001, CI95% = 0.431-0.782), Log10 creatinine (B = 0.081, p = 0.036, CI95% = 0.043-1.239), low-density lipoprotein (B = 0.114, p = 0.003, CI95% = 0.001-0.006) and high-density lipoprotein (B = -0.360, p < 0.001, CI95% = -0.063 to -0.041) were the independent predictors of Trans Atlantic Inter-Society Consensus II class. We have shown that patients with complex peripheral artery disease had complex coronary artery disease.