Manganese()-catalyzed nucleophilic addition of C(sp)-H bonds to aldehydes

The C-H bond activation catalyzed by a manganese( i ) complex has achieved significant development but is limited to C(sp 2 )-H bonds. In this work, an efficient manganese( i )-catalyzed direct nucleophilic addition reaction of C(sp 3 )-H bonds to aromatic aldehydes has been developed. This is the f...

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Published inChemical communications (Cambridge, England) Vol. 6; no. 38; pp. 566 - 569
Main Authors Liu, Hongxin, Tang, Tingyu, Li, Bin, Wang, Baiquan
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 07.05.2024
Royal Society of Chemistry
Subjects
Aldehydes
Bonding
Chemistry
Chemistry, Multidisciplinary
Hydrogen bonds
Manganese
Physical Sciences
Science & Technology
KETONES
MANGANESE
ANNULATION
C-H ACTIVATION
IMINES
CONJUGATE ADDITION
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Summary:The C-H bond activation catalyzed by a manganese( i ) complex has achieved significant development but is limited to C(sp 2 )-H bonds. In this work, an efficient manganese( i )-catalyzed direct nucleophilic addition reaction of C(sp 3 )-H bonds to aromatic aldehydes has been developed. This is the first example of manganese( i )-catalyzed C(sp 3 )-H bond transformation. A manganacycle complex was isolated and proved to be the key active intermediate in the catalytic cycle. Manganese( i )-catalyzed direct nucleophilic addition reaction of C(sp 3 )-H bonds to aromatic aldehydes has been developed. This is the first example of manganese( i )-catalyzed C(sp 3 )-H bond activation.
Bibliography:Electronic supplementary information (ESI) available. CCDC
For ESI and crystallographic data in CIF or other electronic format see DOI
2321505
https://doi.org/10.1039/d4cc01338g
and
2321504
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1359-7345
1364-548X
DOI:10.1039/d4cc01338g