Synthesized β-cyclodextrin modified graphene oxide (β-CD-GO) composite for adsorption of cadmium and their toxicity profile in cervical cancer (HeLa) cell lines

• Published in: Process biochemistry (1991) Vol. 93; pp. 28 - 35
• Main Authors: Samuel, Melvin S., Selvarajan, E., Subramaniam, Kalidass, Mathimani, Thangavel, Seethappan, Sangeetha, Pugazhendhi, Arivalagan
• Format: Journal Article
• Language: English
• Published: Barking Elsevier Ltd 01.06.2020; Elsevier BV
• Subjects: Adsorption; Aqueous solutions; Biotechnology; Cadmium; Cancer; Cell viability; Cervical cancer; Cervix; Composite materials; Construction materials; Cyclodextrin; Cyclodextrins; Electron microscopy; Fourier transforms; Graphene; Graphene oxide; HeLa cell lines; Infrared spectroscopy; Microscopy; Scanning electron microscopy; Synthesis; Toxicity; Transmission electron microscopy; Tumor cell lines; X-ray diffraction; β-Cyclodextrin; HeLa cell lines; Cadmium; Cyclodextrin; Graphene oxide; Toxicity; β-cyclodextrin
• ISSN: 1359-5113; 1873-3298
• DOI: 10.1016/j.procbio.2020.02.014

[Display omitted] •β-cyclodextrin/graphene oxide (β-CD-GO) composite material for the adsorption of Cd(II).•β-CD-GO composite material have high adsorption efficiency of 196 mg/g for Cd(II).•Langmuir isotherm and pseudo second order rate kinetics describe batch sorption.•Toxicity of β-CD-GO composite material was examined in HeLa cells. In the current study, a composite material was constructed using β-cyclodextrin/graphene oxide (β-CD-GO) and was then applied for the purpose of eliminating cadmium (Cd) from aqueous solution. The synthesized β-CD-GO composite material was then subjected to characterization using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The batch study was conducted for the purpose of removing Cd(II). The results of the study revealed that the β-CD-GO composite material demonstrated a high adsorption capacity of 196 mg/g of Cd(II) at pH 7.0. Further, the adsorption of Cd(II) on the β-CD-GO followed pseudo second-order kinetics and equilibrium adsorption data, which fitted well to the Langmuir isotherm model. The evaluation of the toxicity of the synthesized β-CD-GO composite material was done by the examination of the cervical cancer (HeLa) cell lines. Increasing concentration of β-CD-GO composite material (50 μg to 200 μg) leads to a decline in the percentage of cell viability as from 74 % to 25 %. This study has suggested that the β-CD-GO could play an efficient and beneficial source of the adsorbent for the purpose of eliminating Cd(II) from aqueous solution.