Multi-stimuli-responsive molecular fluorescent probes for bioapplications

Stimuli-responsive fluorescent probes have been widely utilized in detecting the physiological and pathological states of living systems. Numerous stimuli-responsive fluorescent probes have been developed due to their advantages of good sensitivity, high resolution, and high contrast fluorescent sig...

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Published inChemical communications (Cambridge, England) Vol. 59; no. 21; pp. 34 - 349
Main Authors Xue, Shan-Shan, Li, Yuanyuan, Pan, Wei, Li, Na, Tang, Bo
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 09.03.2023
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Summary:Stimuli-responsive fluorescent probes have been widely utilized in detecting the physiological and pathological states of living systems. Numerous stimuli-responsive fluorescent probes have been developed due to their advantages of good sensitivity, high resolution, and high contrast fluorescent signals. In this feature article, the progress of multi-stimuli-responsive probes, including organic molecules and metal complexes, for the detection of various biomarkers for bio-applications is summarized. The feature article focuses on the applications of organic-molecule- and metal-complex-based molecular probes in biological systems for detecting different biomarkers of cancer or other diseases. The current challenges and potential future directions of these probes for applications in biological systems are also discussed. This feature article summarizes multi-stimuli molecular fluorescent probes that are based on small organic molecules and metal complexes for bioapplications.
Bibliography:Yuanyuan Li obtained her BS degree in Chemistry from Taishan University (China) in 2021. She is currently pursuing her MS degree at the College of Chemistry, Chemical Engineering and Materials Science at Shandong Normal University. Her current research interests include the design and synthesis of molecular probes as theranostics agents.
Na Li received her BS in 2004 and PhD in 2009 from Shandong University. After a postdoctoral fellowship at McMaster University, Canada, she joined Shandong Normal University in 2010. She became an associate professor in 2012, and was promoted to a full professor in 2014. Her research interests include the design and synthesis of functional nanoprobes for bioanalysis and cancer therapy.
Shan-Shan Xue received her PhD degree in 2017 from Sun Yat-sen University. After postdoctoral experience at Ewha Womans University in Korea, she joined Shandong Normal University as a lecturer in 2021. Her current research interests include the design and synthesis of functional complexes as biosensors and theranostics agents.
Bo Tang obtained his PhD in analytical chemistry in 1994 from Nankai University. Then he joined the College of Chemistry, Chemical Engineering and Materials Science as a full professor at Shandong Normal University. His current research interests include the development of molecular and nano probes for analytical and biomedical applications, solar energy chemical transformation and storage, and the clean synthesis of chemicals.
Wei Pan received his PhD in analytical chemistry from Shandong Normal University in 2014. Currently, he is a professor in the College of Chemistry, Chemical Engineering and Materials Science at Shandong Normal University. His research interests focus on the design and application of fluorescent nanoprobes.
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ISSN:1359-7345
1364-548X
DOI:10.1039/d2cc07008a