Isotachophoretic Analysis of Drugs. II. Determination of Sodium Valproate in Pharmaceutical Preparations

A capillary-tube isotacophoretic procedure for the determination of valproic acid was established. Valproic acid was separated with the following mobile ions : leading electrolyte, 2.5 mM hydrochloric acid in 0.2% polyvinylalcohol adjusted to pH 5.50 by adding L-histidine ; terminating electrolyte,...

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Published inYAKUGAKU ZASSHI Vol. 102; no. 10; pp. 988 - 991
Main Authors TATSUHARA, TOHORU, MURO, HIDEKI, OZOE, FUMIYO
Format Journal Article
LanguageEnglish
Japanese
Published Japan The Pharmaceutical Society of Japan 01.10.1982
Subjects
anticonvulsant
Dosage Forms
Electrophoresis - methods
gaschromatography
Hydrogen-Ion Concentration
isotachophoresis
pharmaceutical analysis
sodium valproate
valproic acid
Valproic Acid - analysis
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Summary:A capillary-tube isotacophoretic procedure for the determination of valproic acid was established. Valproic acid was separated with the following mobile ions : leading electrolyte, 2.5 mM hydrochloric acid in 0.2% polyvinylalcohol adjusted to pH 5.50 by adding L-histidine ; terminating electrolyte, 2.5 mM 2-(N-morpholino) ethanesulfonic acid solution adjusted to pH 7.20 with tris (hydroxymethyl) aminomethane. Commercially available preparations of sodium valproate were determined without pretreatment such as the extraction with organic solvent and the derivation. The values of valproic acid determined by the method were in good agreement with those determined by gas-liquid chromatographic method. This method provides a simple and rapid technique for the determination of valproic acid.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0031-6903
1347-5231
DOI:10.1248/yakushi1947.102.10_988