Paget's disease of bone presenting with multiple cranial nerve palsies: A case report

Paget's disease of bone (PDB) is a progressive monostotic or polyostotic osteopathy with unknown cause. It is associated with the involvement of the nervous system. The cranial nerves, spinal roots, cauda equina, spinal cord, and brain can be affected in PDB due to their close anatomical relati...

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Bibliographic Details
Published inRadiology case reports Vol. 17; no. 6; pp. 1870 - 1873
Main Authors Hamid, M., Touarsa, F., Satte, A., Bourazza, A.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Inc 01.06.2022
Elsevier
Subjects
Bisphosphonates
Case Report
Multiple cranial nerve palsies
Paget's disease of bone
Sphenoid bone
Sphenoid bone
Bisphosphonates
Multiple cranial nerve palsies
Paget's disease of bone
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Summary:Paget's disease of bone (PDB) is a progressive monostotic or polyostotic osteopathy with unknown cause. It is associated with the involvement of the nervous system. The cranial nerves, spinal roots, cauda equina, spinal cord, and brain can be affected in PDB due to their close anatomical relation to bone. Hearing loss occurs in 12%-50% of patients with PDB. The optic nerve can be affected at the optic canal. The diagnosis of PDB is radiological by highlighting characteristic lesions like thickening of the cortical bone, hypertrophic and fibrillary bones. Progressive or chronic neurological deficits should be treated with bisphosphonates. We present a rare case of multiple cranial nerve palsies as the first manifestation of PDB.
ISSN:1930-0433
1930-0433
DOI:10.1016/j.radcr.2022.03.028