Changes of Nerve Growth Factor in Amniotic Fluid and Correlation with Ventriculomegaly

• Published in: Chinese medical sciences journal Vol. 26; no. 2; pp. 109 - 112
• Main Authors: Xia, Xiao-yan, Huang, Xing-hua, Xia, Yi-xin, Zhang, Wei-hua
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01.06.2011; Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital,Capital Medical University, Beijing 100026, China%Department of Obstetrics and Gynecology, General Hospital of Armed Police Forces, Beijing 100039, China
• Subjects: Adult; amniotic fluid; Amniotic Fluid - chemistry; Female; fetal ventriculomegaly; Humans; Hydrocephalus - metabolism; nerve growth factor; Nerve Growth Factor - analysis; NGF; Pregnancy; 妊娠期; 对照组; 神经生长因子; 羊水; 脑; 试验检测; 酶联免疫吸附; nerve growth factor; fetal ventriculomegaly; amniotic fluid
• ISSN: 1001-9294
• DOI: 10.1016/S1001-9294(11)60029-1

Objective To detect the change of nerve growth factor （NGF） level in human amniotic fluid during gestation, and to explore the relationship between this change and fetal ventriculomegaly （VM）. Methods The studied subjects （collected from 2004 to 2007） were divided into four groups, including the second-trimester pregnancy group （n=113）, third-trimester pregnancy group （n=110）, fetal cerebral VM group （n=12）, and healthy control group （n=12） which matched with the VM group in gesta- tional weeks. The amniotic fluid specimens were obtained during amniocentesis or cesarean section. The NGF levels in amniotic fluid were detected with enzyme-linked immunosorbent assay. Results A significantly negative correlation was found between gestational age and the NGF level in amniotic fluid （r=-0.6149, P〈0.0001）. The N GF level in patients with fetal VM was significantly lower than that in healthy controls （33.95±29.24 pg/mL vs. 64.73±16.21 pg/mL, P=0.024）. Conclusion NGF levels in amniotic fluid may be a sensitive marker for fetalVM.