Anti-inflammatory response to 1,8-Cineol and associated microbial communities in Otitis media patients

• Published in: Scientific reports Vol. 14; no. 1; pp. 16362 - 10
• Main Authors: Leichtle, Anke, Lupatsii, Mariia, Graspeuntner, Simon, Jeschke, Stephanie, Penxová, Zuzana, Kurabi, Arwa, Ryan, Allen Frederic, Rupp, Jan, Pries, Ralph, Bruchhage, Karl-Ludwig
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 16.07.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 1,8-Cineol; 631/326; 692/308; 692/699; 692/700; Adult; Aged; Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; Antibiotic resistance; Antibiotics; Chronic otitis media; Ear canal; Ear diseases; Female; Humanities and Social Sciences; Humans; Inflammation; Male; Microbial activity; Microbiota; Microbiota - drug effects; Middle Aged; Middle ear; multidisciplinary; Otitis media; Otitis Media - drug therapy; Otitis Media - microbiology; Pathogens; Patients; Proteus mirabilis - drug effects; Pseudomonas aeruginosa - drug effects; Pseudomonas aeruginosa - isolation & purification; Science; Science (multidisciplinary); Tympanic membrane; Pathogens; 1,8-Cineol; Clinical outcome; Microbiota; Eucalyptus oil; Chronic otitis media; Antibiotic resistance; Inflammation

Chronic Otitis Media (COM) is defined as long term inflammation and colonization with pathogenic bacteria due to a defect or retraction of the tympanic membrane. Surgical interventions are often augmented by antibiotic resistance development and therefore, off-label treatment using the natural drug...