Anti-inflammatory response to 1,8-Cineol and associated microbial communities in Otitis media patients

• Published in: Scientific reports Vol. 14; no. 1; pp. 16362 - 10
• Main Authors: Leichtle, Anke, Lupatsii, Mariia, Graspeuntner, Simon, Jeschke, Stephanie, Penxová, Zuzana, Kurabi, Arwa, Ryan, Allen Frederic, Rupp, Jan, Pries, Ralph, Bruchhage, Karl-Ludwig
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 16.07.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 1,8-Cineol; 631/326; 692/308; 692/699; 692/700; Adult; Aged; Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; Antibiotic resistance; Antibiotics; Chronic otitis media; Ear canal; Ear diseases; Female; Humanities and Social Sciences; Humans; Inflammation; Male; Microbial activity; Microbiota; Microbiota - drug effects; Middle Aged; Middle ear; multidisciplinary; Otitis media; Otitis Media - drug therapy; Otitis Media - microbiology; Pathogens; Patients; Proteus mirabilis - drug effects; Pseudomonas aeruginosa - drug effects; Pseudomonas aeruginosa - isolation & purification; Science; Science (multidisciplinary); Tympanic membrane; Pathogens; 1,8-Cineol; Clinical outcome; Microbiota; Eucalyptus oil; Chronic otitis media; Antibiotic resistance; Inflammation
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-67498-5

Chronic Otitis Media (COM) is defined as long term inflammation and colonization with pathogenic bacteria due to a defect or retraction of the tympanic membrane. Surgical interventions are often augmented by antibiotic resistance development and therefore, off-label treatment using the natural drug 1,8-Cineol was carried out. All COM patients underwent antibiotic therapy and middle ear surgery and developed antibiotic resistances. Microbiological investigations from the auditory canal and stool samples were performed in correlation with the clinical course. Therapy of COM patients with 1,8-Cineol revealed a clear reduction of inflammatory microbes P. aeruginosa and Proteus mirabilis in ear samples as well as intestinal Prevotella copri , which was associated with an improved clinical outcome in certain individuals. The present off-label study revealed manifold anti-inflammatory effects of the natural monoterpene 1,8-Cineol in Otitis media patients. A better understanding of the underlying mechanisms will improve the current treatment options and possible forms of application of this natural drug.