High Resolution Anoscopy Findings for Men Who Have Sex with Men: Inaccuracy of Anal Cytology as a Predictor of Histologic High-Grade Anal Intraepithelial Neoplasia and the Impact of HIV Serostatus

• Published in: Clinical infectious diseases Vol. 38; no. 10; pp. 1490 - 1492
• Main Authors: Panther, Lori A., Wagner, Katiri, Proper, JoAnn, Fugelso, Dana K., Chatis, Pamela A., Weeden, Will, Nasser, Imad A., Doweiko, John P., Dezube, Bruce J.
• Format: Journal Article
• Language: English
• Published: Chicago, IL The University of Chicago Press 15.05.2004; University of Chicago Press
• Subjects: Anus Diseases - epidemiology; Anus Diseases - pathology; Anus Neoplasms - epidemiology; Anus Neoplasms - pathology; Biological and medical sciences; Biopsies; Biopsy; Histology; HIV; HIV Seropositivity; HIV/AIDS; Homosexuality, Male; Human viral diseases; Humans; Infectious diseases; Interstitial nephritis; Lesions; Male; Medical sciences; Men; Papanicolaou Test; Pathology; Squamous cell carcinoma; Squamous cell neoplasms; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Surgical biopsy; Human; Immunopathology; Dysplasia; Homosexuality; Excision; Cytology; Retroviridae; Male; AIDS; Immune deficiency; Lentivirus; Infection; Virus; Treatment; Anus; Surgery; Viral disease; Smear; Diagnosis; Human immunodeficiency virus; Predictive factor; Intraepithelial neoplasia; Comparative study
• ISSN: 1058-4838; 1537-6591
• DOI: 10.1086/383574

We compared the pathological diagnoses obtained by anal Papanicolaou (Pap) smear with those obtained by anal biopsy or by surgical excision for 153 men who have sex with men (MSM). Analysis of these paired specimens showed that anal Pap smears were an inaccurate predictor of high-grade anal dysplasia, regardless of human immunodeficiency virus (HIV) serostatus. The presence of any abnormal anal cytological finding indicates a potential for high-grade dysplasia on histological examination of MSM.