The antiarrhythmic effects of Sophora flavescens Ait. in rats and mice

The effects of an ethanol extract of the plant Sophora flavescens Ait. on cardiac arrhythmias induced by coronary artery ligation in rats, and by aconitine infusion in mice, were studied. Pretreatment with intravenous injection of the extract, 120 mg/kg, significantly reduced the incidence and delay...

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Bibliographic Details
Published inThe American journal of Chinese medicine (1979) Vol. 14; no. 3-4; p. 119
Main Authors Dai, S, Chan, M Y, Lee, S S, Ogle, C W
Format Journal Article
LanguageEnglish
Published Singapore 1986
Subjects
Aconitine
Animals
Anti-Arrhythmia Agents
Arrhythmias, Cardiac - chemically induced
Arrhythmias, Cardiac - drug therapy
Arrhythmias, Cardiac - etiology
Coronary Vessels - surgery
Ligation
Male
Medicine, Chinese Traditional
Medicine, East Asian Traditional
Mice
Mice, Inbred ICR
Plant Extracts - pharmacology
Plants, Medicinal
Rats
Rats, Inbred Strains
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Summary:The effects of an ethanol extract of the plant Sophora flavescens Ait. on cardiac arrhythmias induced by coronary artery ligation in rats, and by aconitine infusion in mice, were studied. Pretreatment with intravenous injection of the extract, 120 mg/kg, significantly reduced the incidence and delayed the onset of ventricular tachycardia in rats subjected to ligation of the left coronary artery. The time of onset of both initial cardiac arrhythmias and persistent ventricular tachycardia induced by aconitine infusion in mice was also significantly prolonged. These preliminary findings suggest that the ethanol extract of Sophora flavescens Ait. possesses antiarrhythmic activity.
ISSN:0192-415X
1793-6853
DOI:10.1142/S0192415X86000193